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Genetic polymorphisms in cytotoxic T-lymphocyte antigen 4 and cancer: the dialectical nature of subtle human immune dysregulation.

Cancer research - 1 Aug 2009

Sun Tong, Hu Zhibin, Shen Hongbing, Lin Dongxin

Abstract excerpt

Genetic polymorphisms in the human genome are an important component of genotypic variability including one's immune status. Single nucleotide polymorphisms (SNPs) in the cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene have been linked to susceptibility to autoimmune disease. Interestingly, we have recently shown that an SNP in the CTLA-4 coding region (49A > G) is also associated with susceptibility to human...

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Antigens, CD
CTLA-4 Antigen
Genetic Predisposition to Disease
Neoplasms
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19638588
DOI: 10.1158/0008-5472.CAN-09-0176

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