Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell-specific effects in different immune subsets associated with SOCS1 genotypes in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Oct 2015

Lopez de Lapuente Aitzkoa, Pinto-Medel María Jesús, Astobiza Ianire, Alloza Iraide, Comabella Manuel, Malhotra Sunny, Montalban Xavier, Zettl Uwe K, Rodríguez-Antigüedad Alfredo, Fernández Oscar, Vandenbroeck Koen

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms (SNPs) near SOCS1 are associated with multiple sclerosis (MS), but the most important SNPs in the area and mechanisms by which they influence the disease are unknown. METHODS: A haplotype-tagging association study was performed covering 60.5kbp around SOCS1, and the index SNP was validated in a total of 2292 individuals. mRNA expression of SOCS1 and nearby genes was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD1
Share to B7-2 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dendritic Cells

Share to Monocytes

Share to Multiple Sclerosis, Chronic Progressive

Share to Multiple Sclerosis, Relapsing-Remitting

Share to Suppressor of Cytokine Signaling 1 Protein

Share to Suppressor of Cytokine Signaling Proteins

Source

Identifiers

PMID: 25623250
DOI: 10.1177/1352458514566418

Genes

SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell-specific effects in different immune subsets associated with SOCS1 genotypes in multiple sclerosis.PMID 25623250Read ↗

Expression of suppressor of cytokine signaling 1 (SOCS1) gene dramatically increases in relapsing-remitting multiple sclerosis.Semantic proximity Read ↗

Neurological Phenotypes of SOCS1 Haploinsufficiency: Insights from Functional and Histological Investigations.Semantic proximity Read ↗

The Polygenic Nature of Multiple Sclerosis: Genetic Variants, Immunological Modulation, and Environmental ConnectionsSemantic proximity Read ↗

The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis.Semantic proximity Read ↗

Identification of a Human SOCS1 Polymorphism That Predicts Rheumatoid Arthritis Severity.Semantic proximity Read ↗

TLR3 polymorphism protects against multiple sclerosis onset but not progression in Egyptian patients.Semantic proximity Read ↗

A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis.Semantic proximity Read ↗

Oligodendroglia as functional effectors of Multiple Sclerosis risk variantsSemantic proximity Read ↗

Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing.Semantic proximity Read ↗

Immune-Related Gene Variants as Modifiers of Multiple Sclerosis Severity.Semantic proximity Read ↗

Differential expression of SOCS1 in macrophages in relapsing‐remitting and chronic EAE and its role in disease severitySemantic proximity Read ↗

Genome-wide association study of severity in multiple sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.