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Article

Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2002

Sakata Yasuhiko, Kamei Caramai N, Nakagami Hironori, Bronson Roderick, Liao James K, Chin Michael T

Abstract excerpt

Ventricular septal defects are common in human infants, but the genetic programs that control ventricular septation are poorly understood. Here we report that mice with a targeted disruption of the cardiovascular basic helix-loop-helix factor (CHF)1Hey2 gene show isolated ventricular septal defects. These defects result primarily in failure to thrive. Mice often succumbed within the first 3 wk after birth and...

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Identifiers

PMID: 12454287
DOI: 10.1073/pnas.252648999
PMCID: PMC138588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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