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Mouse gridlock: no aortic coarctation or deficiency, but fatal cardiac defects in Hey2 -/- mice.

Current biology : CB - 17 Sept 2002

Gessler Manfred, Knobeloch Klaus-Peter, Helisch Armin, Amann Kerstin, Schumacher Nina, Rohde Elvira, Fischer Andreas, Leimeister Cornelia

Abstract excerpt

Gridlock (grl) is one of the first mutations characterized from the large zebrafish mutagenesis screens, and it results in an arterial (aortic) maturation defect, which was proposed to resemble aortic coarctation, a clinically important human malformation. While the grl mutation appears to be a hypomorph, grl knockdown experiments have shown even stronger effects on arterial development. We have generated a...

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PMID: 12372253
DOI: 10.1016/s0960-9822(02)01150-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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