Article
Mouse gridlock: no aortic coarctation or deficiency, but fatal cardiac defects in Hey2 -/- mice.
Current biology : CB - 17 Sept 2002
Gessler Manfred, Knobeloch Klaus-Peter, Helisch Armin, Amann Kerstin, Schumacher Nina, Rohde Elvira, Fischer Andreas, Leimeister Cornelia
Abstract excerpt
Gridlock (grl) is one of the first mutations characterized from the large zebrafish mutagenesis screens, and it results in an arterial (aortic) maturation defect, which was proposed to resemble aortic coarctation, a clinically important human malformation. While the grl mutation appears to be a hypomorph, grl knockdown experiments have shown even stronger effects on arterial development. We have generated a...
Topics
- Animals
- Aortic Coarctation
- Basic Helix-Loop-Helix Transcription Factors
- Biological Evolution
- Cardiomyopathy, Hypertrophic, Familial
- Gene Expression
- Humans
- In Situ Hybridization
- Mice
- Mice, Knockout