Article

Chronic Perinatal Hypoxia Delays Cardiac Maturation in a Mouse Model for Cyanotic Congenital Heart Disease

2020-05-30

Abstract excerpt

<h4>Background</h4> Compared to acyanotic congenital heart disease (CHD), cyanotic CHD has an increased risk of lifelong mortality and morbidity. These adverse outcomes may be attributed to delayed cardiomyocyte maturation, since the transition from a hypoxic fetal milieu to oxygen rich postnatal environment is disrupted. We established a rodent model to replicate hypoxic myocardial conditions spanning perinatal...

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Literature Corpus work: 5a66eea9-6510-5aa8-89ec-640109baa927
DOI: 10.1101/2020.05.28.117648

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