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Article

cAMP induces ABCA1 phosphorylation activity and promotes cholesterol efflux from fibroblasts.

Journal of lipid research - 1 Dec 2002

Haidar Bassam, Denis Maxime, Krimbou Larbi, Marcil Michel, Genest Jacques

Abstract excerpt

ATP-binding cassette transporter A1 (ABCA1) plays a crucial role in apoA-I lipidation, a key step in reverse cholesterol transport. cAMP induces apoA-I binding activity and promotes cellular cholesterol efflux. We investigated the role of the cAMP/protein kinase A (PKA) dependent pathway in the regulation of cellular cholesterol efflux. Treatment of normal fibroblasts with 8-bromo-cAMP (8-Br-cAMP) increased...

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Source

Identifiers

PMID: 12454270
DOI: 10.1194/jlr.m200235-jlr200

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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