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Article

cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b.

The Journal of biological chemistry - 6 Sept 2002

Lou Liguang, Urbani Julie, Ribeiro-Neto Fernando, Altschuler Daniel L

Abstract excerpt

Rap1b has been implicated in the transduction of the cAMP mitogenic signal. Rap1b is phosphorylated and activated by cAMP, and its expression in cells where cAMP is mitogenic leads to an increase in G(1)/S phase entry and tumor formation. The PCCL3 thyroid follicular cells represent a differentiated and physiologically relevant system that requires thyrotropin (TSH), acting via cAMP, for a full mitogenic...

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Source

Identifiers

PMID: 12089143
DOI: 10.1074/jbc.M201491200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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