Article

Phosphodiesterase type 1 regulates adenosine 2A receptor-associated cAMP signaling at the plasma membrane to increase myocardial contractility

2025-10-05

Abstract excerpt

<h4>BACKGROUND</h4> Phosphodiesterase type 1 (PDE1) inhibition exerts inodilatory effects in pre-clinical models and human heart failure patients with reduced ejection fraction (HFrEF). PDE1 hydrolyzes cyclic nucleotide cAMP in a soluble but not microsomal fraction of the human myocardium. PDE1 may exert domain-specific effects, but the mechanism whereby PDE1 compartmentalization induces an inotropic change remai...

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Literature Corpus work: c8013b12-60cb-5e2e-a2d8-eccc4d8304f2
DOI: 10.1101/2025.10.03.680406

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