Article
ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein.
The Journal of biological chemistry - 29 Jun 2001
Wang N, Silver D L, Thiele C, Tall A R
Abstract excerpt
ABCA1, an ATP-binding cassette transporter mutated in Tangier disease, promotes cellular phospholipid and cholesterol efflux by loading free apoA-I with these lipids. This process involves binding of apoA-I to the cell surface and phospholipid translocation by ABCA1. The goals of this study were to examine the relationship between ABCA1-mediated lipid efflux and apolipoprotein binding and to determine whether...
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