Article
Post-transcriptional contribution of a cAMP-dependent pathway to the formation of alpha- and beta/gamma-secretases-derived products of beta APP maturation in human cells expressing wild-type and Swedish mutated beta APP.
Molecular medicine (Cambridge, Mass.) - 1 Nov 1998
Marambaud P, Chevallier N, Ancolio K, Checler F
Abstract excerpt
BACKGROUND: The physiopathological maturation of the beta-amyloid precursor protein can be modulated by effectors targeting a protein kinase C-dependent pathway. These agents increase the recovery of APP alpha, the physiological alpha-secretase-derived product of beta APP processing, and concomit...
Topics
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor
- Aspartic Acid Endopeptidases
- Bucladesine
- Cell Line
- Colforsin
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Dactinomycin
- Endopeptidases