Article
Control of cAMP in lung endothelial cell phenotypes. Implications for control of barrier function.
The American journal of physiology - 1 Jul 1999
Stevens T, Creighton J, Thompson W J
Abstract excerpt
Pulmonary microvascular endothelial cells (PMVECs) form a more restrictive barrier to macromolecular flux than pulmonary arterial endothelial cells (PAECs); however, the mechanisms responsible for this intrinsic feature of PMVECs are unknown. Because cAMP improves endothelial barrier function, we hypothesized that differences in enzyme regulation of cAMP synthesis and/or degradation uniquely establish an elevated...
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