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Article

Janus kinase 2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol.

The Journal of biological chemistry - 27 Feb 2004

Tang Chongren, Vaughan Ashley M, Oram John F

Abstract excerpt

ATP-binding cassette transporter A1 (ABCA1) mediates transport of cellular cholesterol and phospholipids to high density lipoprotein (HDL) apolipoproteins, such as apoA-I. ABCA1 mutations can cause a severe HDL deficiency and atherosclerosis. Here we show that the protein-tyrosine kinase (TK) Janus kinase 2 (JAK2) modulates the apolipoprotein interactions with ABCA1 required for removing cellular lipids. The...

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Source

Identifiers

PMID: 14668333
DOI: 10.1074/jbc.M312571200

Genes

ABCA1
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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