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Article

TM2-TM7 interaction in coupling movement of transmembrane helices to activation of the angiotensin II type-1 receptor.

The Journal of biological chemistry - 7 Feb 2003

Miura Shin-ichiro, Zhang Jingli, Boros John, Karnik Sadashiva S

Abstract excerpt

Agonist-induced rigid body motion of transmembrane (TM) helices has been established as a unifying mechanism in the activation of the G protein-coupled receptors. In attempts to measure specific conformational transitions during the activation of the type 1 receptor for angiotensin II (AT(1)), we found a decrease in accessibility of Cys(76) in the second TM helix, suggesting that the orientation of TM2 is altered...

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Identifiers

PMID: 12446719
DOI: 10.1074/jbc.M211338200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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