Article
The fifth transmembrane domain of angiotensin II Type 1 receptor participates in the formation of the ligand-binding pocket and undergoes a counterclockwise rotation upon receptor activation.
The Journal of biological chemistry - 13 Nov 2009
Domazet Ivana, Martin Stéphane S, Holleran Brian J, Morin Marie-Eve, Lacasse Patrick, Lavigne Pierre, Escher Emanuel, Leduc Richard, Guillemette Gaétan
Abstract excerpt
The octapeptide hormone angiotensin II exerts a wide variety of cardiovascular effects through the activation of the angiotensin II Type 1 (AT(1)) receptor, which belongs to the G protein-coupled receptor superfamily. Like other G protein- coupled receptors, the AT(1) receptor possesses seven transmembrane domains that provide structural support for the formation of the ligand-binding pocket. The role of the...
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