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Article

Analysis of the third transmembrane domain of the human type 1 angiotensin II receptor by cysteine scanning mutagenesis.

The Journal of biological chemistry - 3 Dec 2004

Martin Stéphane S, Boucard Antony A, Clément Martin, Escher Emanuel, Leduc Richard, Guillemette Gaétan

Abstract excerpt

Activation of G protein-coupled receptors by agonists involves significant movement of transmembrane domains (TMD) following agonist binding. The underlying structural mechanism by which receptor activation takes place is largely unknown but can be inferred by detecting variability within the environment of the ligand-binding pocket, which is a water-accessible crevice surrounded by the seven TMD helices. Using...

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PMID: 15452107
DOI: 10.1074/jbc.M407965200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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