Article
The functional microdomain in transmembrane helices 2 and 7 regulates expression, activation, and coupling pathways of the gonadotropin-releasing hormone receptor.
The Journal of biological chemistry - 8 Oct 1999
Flanagan C A, Zhou W, Chi L, Yuen T, Rodic V, Robertson D, Johnson M, Holland P, Millar R P, Weinstein H, Mitchell R, Sealfon S C
Abstract excerpt
Structural microdomains of G protein-coupled receptors (GPCRs) consist of spatially related side chains that mediate discrete functions. The conserved helix 2/helix 7 microdomain was identified because the gonadotropin-releasing hormone (GnRH) receptor appears to have interchanged the Asp(2.50) and Asn(7.49) residues which are conserved in transmembrane helices 2 and 7 of rhodopsin-like GPCRs. We now demonstrate...
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