Article
A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor.
Molecular pharmacology - 1 Feb 1994
Zhou W, Flanagan C, Ballesteros J A, Konvicka K, Davidson J S, Weinstein H, Millar R P, Sealfon S C
Abstract excerpt
Activation of the pituitary gonadotropin-releasing hormone receptor, a member of the seven-transmembrane G protein-coupled receptor (GPCR) family, triggers a cascade of events leading to gonadotropin release and stimulation of the reproductive system. An unusual feature of this receptor, observed in mice, rats, and humans, is the presence of Asn87 in the second putative transmembrane helix at the location of a...
Topics
- Amino Acid Sequence
- Animals
- Cell Membrane
- DNA, Complementary
- Inositol Phosphates
- Mice
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Protein Conformation