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Article

A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor.

Molecular pharmacology - 1 Feb 1994

Zhou W, Flanagan C, Ballesteros J A, Konvicka K, Davidson J S, Weinstein H, Millar R P, Sealfon S C

Abstract excerpt

Activation of the pituitary gonadotropin-releasing hormone receptor, a member of the seven-transmembrane G protein-coupled receptor (GPCR) family, triggers a cascade of events leading to gonadotropin release and stimulation of the reproductive system. An unusual feature of this receptor, observed in mice, rats, and humans, is the presence of Asn87 in the second putative transmembrane helix at the location of a...

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PMID: 8114667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor.PMID 8114667Read ↗

The functional microdomain in transmembrane helices 2 and 7 regulates expression, activation, and coupling pathways of the gonadotropin-releasing hormone receptor.Semantic proximity Read ↗

Multiple interactions of the Asp(2.61(98)) side chain of the gonadotropin-releasing hormone receptor contribute differentially to ligand interaction.Semantic proximity Read ↗

Reciprocal mutations of highly conserved residues in transmembrane helices 2 and 7 of the alpha(2A)-adrenoceptor restore agonist activation of G(i1)alpha.Semantic proximity Read ↗

Asp330 and Tyr331 in the C-terminal cysteine-rich region of the luteinizing hormone receptor are key residues in hormone-induced receptor activation.Semantic proximity Read ↗

Salt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation.Semantic proximity Read ↗

Related contribution of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor.Semantic proximity Read ↗

Highly conserved serine in the third transmembrane helix of the luteinizing hormone/human chorionic gonadotropin receptor regulates receptor activation.Semantic proximity Read ↗

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Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization.Semantic proximity Read ↗

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