Article
Control of biochemical reactions through supramolecular RING domain self-assembly.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2002
Kentsis Alex, Gordon Ronald E, Borden Katherine L B
Abstract excerpt
RING domains act in a variety of unrelated biochemical reactions, with many of these domains forming key parts of supramolecular assemblies in cells. Here, we observe that purified RINGs from a variety of functionally unrelated proteins, including promyelocytic leukemia protein, KAP-1TIF1beta, Z, Mel18, breast cancer susceptibility gene product 1 (BRCA1), and BRCA1-associated RING domain (BARD1), self-assemble...
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