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Article

Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation.

Molecular cell - 2 Mar 2023

Cuneo Matthew J, O'Flynn Brian G, Lo Yu-Hua, Sabri Nafiseh, Mittag Tanja

Abstract excerpt

The speckle-type POZ protein (SPOP) functions in the Cullin3-RING ubiquitin ligase (CRL3) as a receptor for the recognition of substrates involved in cell growth, survival, and signaling. SPOP mutations have been attributed to the development of many types of cancers, including prostate and endometrial cancers. Prostate cancer mutations localize in the substrate-binding site of the substrate recognition (MATH)...

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Identifiers

PMID: 36693379
DOI: 10.1016/j.molcel.2022.12.033
PMCID: PMC9992347

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