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Article

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.

Nature structural biology - 1 Oct 2001

Brzovic P S, Rajagopal P, Hoyt D W, King M C, Klevit R E

Abstract excerpt

The RING domain of the breast and ovarian cancer tumor suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mutations found within this domain. We present the solution structure of the heterodimer formed between the RING domains of BRCA1 and BARD1. Comparison with the RING...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11573085
DOI: 10.1038/nsb1001-833

Genes

BRCA1
BARD1
RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.PMID 11573085Read ↗

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