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Reciprocal targeting of the unfolded protein response regulator Xbp1 and the Dom-A nucleosome remodeler in <i>Drosophila</i>

2025-10-15

Abstract excerpt

The DOM-A complex regulates cell growth and proliferation in Drosophila . Like the orthologous human P400 complex, DOM-A combines two epigenetic effectors: a SWR1-type histone exchange enzyme, Dom-A, and the Tip60 acetyltransferase. We found Xbp1, a conserved transcription regulator of the unfolded protein response (UPR), as tightly associated with immunopurified DOM-A and explored the functional implications of...

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Identifiers and source

Literature Corpus work
6da03bce-371f-5509-a196-23fd5834313c
DOI
10.1101/2025.10.15.682518
Open publication

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