Article
Dimerization quality control ensures neuronal development and survival.
Science (New York, N.Y.) - 12 Oct 2018
Mena Elijah L, Kjolby Rachel A S, Saxton Robert A, Werner Achim, Lew Brandon G, Boyle John M, Harland Richard, Rape Michael
Abstract excerpt
Aberrant complex formation by recurrent interaction modules, such as BTB domains, leucine zippers, or coiled coils, can disrupt signal transduction, yet whether cells detect and eliminate complexes of irregular composition is unknown. By searching for regulators of the BTB family, we discovered a quality control pathway that ensures functional dimerization [dimerization quality control (DQC)]. Key to this network...
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