Article
Link functions in multi-locus genetic models: implications for testing, prediction, and interpretation.
Genetic epidemiology - 1 May 2012
Clayton David
Abstract excerpt
"Complex" diseases are, by definition, influenced by multiple causes, both genetic and environmental, and statistical work on the joint action of multiple risk factors has, for more than 40 years, been dominated by the generalized linear model (GLM). In genetics, models for dichotomous traits have traditionally been approached via the model of an underlying, normally distributed, liability. This corresponds to...
Topics
- Algorithms
- Epistasis, Genetic
- False Positive Reactions
- Genetic Linkage
- Genotype
- Humans
- Linear Models
- Models, Genetic
- Models, Statistical
- Models, Theoretical
- Phenotype
- ROC Curve