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Article

CYP2C9 genetic variants and losartan oxidation in a Turkish population.

European journal of clinical pharmacology - 1 Jul 2004

Babaoglu Melih O, Yasar Umit, Sandberg Mia, Eliasson Erik, Dahl Marja-Liisa, Kayaalp S Oguz, Bozkurt Atila

Abstract excerpt

OBJECTIVE: Cytochrome P(450) 2C9 (CYP2C9) is a polymorphic enzyme catalysing the metabolism of several important drugs. Losartan has recently been suggested as a selective probe for CYP2C9 metabolic activity. The aim of the study was to determine the activity of CYP2C9, using losartan as a probe drug, in relation to CYP2C9 genotype in healthy Turkish subjects. METHODS: A single oral dose of 25 mg losartan was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15197523
DOI: 10.1007/s00228-004-0785-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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