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Article

5'-Flanking region polymorphisms of CYP2C9 and their relationship to S-warfarin metabolism in white and Japanese patients.

Blood - 15 Apr 2004

Takahashi Harumi, Ieiri Ichiro, Wilkinson Grant R, Mayo Gail, Kashima Toshitaka, Kimura Sosuke, Otsubo Kenji, Echizen Hirotoshi

Abstract excerpt

White and Japanese patients require different warfarin dosages to achieve therapeutic anticoagulation, but this can be only partly explained by genetic variability in the coding region of CYP2C9-a critical enzyme in the drug's metabolism. Accordingly, analysis of the -2.1-kb 5'-flanking region of...

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Identifiers

PMID: 15070684
DOI: 10.1182/blood-2003-07-2521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15070684-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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