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Article

p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase.

Molecular cancer research : MCR - 1 Aug 2010

Zemskova Marina, Lilly Michael B, Lin Ying-Wei, Song Jin H, Kraft Andrew S

Abstract excerpt

The PIM family of serine threonine protein kinases plays an important role in regulating both the growth and transformation of malignant cells. However, in a cell line-dependent manner, overexpression of PIM1 can inhibit cell and tumor growth. In 22Rv1 human prostate cells, but not in Du145 or RWPE-2, PIM1 overexpression was associated with marked increases in cellular senescence, as shown by changes in the...

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Source

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Identifiers

PMID: 20647331
DOI: 10.1158/1541-7786.MCR-10-0174
PMCID: PMC3407470

Genes

PIM1
DDIT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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