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Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity

9 May 2006

Abstract excerpt

BACKGROUND: The pim family genes encode oncogenic serine/threonine kinases which in hematopoietic cells have been implicated in cytokine-dependent signaling as well as in lymphomagenesis, especially in cooperation with other oncogenes such as myc, bcl-2 or Runx family genes. The Runx genes encode alpha-subunits of heterodimeric transcription factors which regulate cell proliferation and differentiation in various...

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PMID: 16684349
DOI: 10.1186/1471-2121-7-21

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