Article
Identification and characterization of two unusual cGMP-stimulated phoshodiesterases in dictyostelium.
Molecular biology of the cell - 1 Nov 2002
Bosgraaf Leonard, Russcher Henk, Snippe Helena, Bader Sonya, Wind Joyce, Van Haastert Peter J M
Abstract excerpt
Recently, we recognized two genes, gbpA and gbpB, encoding putative cGMP-binding proteins with a Zn(2+)-hydrolase domain and two cyclic nucleotide binding domains. The Zn(2+)-hydrolase domains belong to the superfamily of beta-lactamases, also harboring a small family of class II phosphodiesterases from bacteria and lower eukaryotes. Gene inactivation and overexpression studies demonstrate that gbpA encodes the...
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