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Article

Identification of a novel type of cGMP phosphodiesterase that is defective in the chemotactic stmF mutants.

Molecular biology of the cell - 1 Nov 2002

Meima Marcel E, Biondi Ricardo M, Schaap Pauline

Abstract excerpt

StmF mutants are chemotactic mutants that are defective in a cGMP phosphodiesterase (PDE) activity. We identified a novel gene, PdeD, that harbors two cyclic nucleotide-binding domains and a metallo-beta-lactamase homology domain. Similar to stmF mutants, pdeD-null mutants displayed extensively streaming aggregates, prolonged elevation of cGMP levels after chemotactic stimulation, and reduced cGMP-PDE activity....

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Source

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Identifiers

PMID: 12429831
DOI: 10.1091/mbc.e02-05-0285
PMCID: PMC133599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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