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Article

Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclic‐di‐guanosine monophosphate in motility and virulence

28 Apr 2010

Abstract excerpt

The genome of Borrelia burgdorferi encodes a set of genes putatively involved in cyclic-dimeric guanosine monophosphate (cyclic-di-GMP) metabolism. Although BB0419 was shown to be a diguanylate cyclase, the extent to which bb0419 or any of the putative cyclic-di-GMP metabolizing genes impact B. burgdorferi motility and pathogenesis has not yet been reported. Here we identify and characterize a phosphodiesterase...

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PMID: 20444101
DOI: 10.1111/j.1365-2958.2010.07191.x

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