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Article

Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC.

The Journal of biological chemistry - 31 Oct 2008

van Egmond Wouter N, Kortholt Arjan, Plak Katarzyna, Bosgraaf Leonard, Bosgraaf Sylvia, Keizer-Gunnink Ineke, van Haastert Peter J M

Abstract excerpt

GbpC is a large multidomain protein involved in cGMP-mediated chemotaxis in the cellular slime mold Dictyostelium discoideum. GbpC belongs to the Roco family of proteins that often share a central core region, consisting of leucine-rich repeats, a Ras domain (Roc), a Cor domain, and a MAPKKKinase domain. In addition to this core, GbpC contains a RasGEF domain and two cGMP-binding domains. Here, we report on an...

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Identifiers

PMID: 18703517
DOI: 10.1074/jbc.M804265200
PMCID: PMC2662088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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