Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium.

Journal of cell science - 1 May 2005

Bosgraaf Leonard, Waijer Arjen, Engel Ruchira, Visser Antonie J W G, Wessels Deborah, Soll David, van Haastert Peter J M

Abstract excerpt

The regulation of cell polarity plays an important role in chemotaxis. Previously, two proteins termed GbpC and GbpD were identified in Dictyostelium, which contain RasGEF and cyclic nucleotide binding domains. Here we show that gbpC-null cells display strongly reduced chemotaxis, because they are unable to polarise effectively in a chemotactic gradient. However, gbpD-null mutants exhibit the opposite phenotype:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cell Adhesion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemotaxis

Share to Cyclic AMP

Share to Cyclic GMP

Share to Dictyostelium

Share to Myosin Type II

Share to Myosins

Source

Identifiers

PMID: 15827084
DOI: 10.1242/jcs.02317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium.PMID 15827084Read ↗

An unconventional myosin required for cell polarization and chemotaxis.Semantic proximity Read ↗

Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis.Semantic proximity Read ↗

A novel Dictyostelium RasGEF required for chemotaxis and development.Semantic proximity Read ↗

The role of cGMP and the rear of the cell in Dictyostelium chemotaxis and cell streaming.Semantic proximity Read ↗

PIP₃-dependent macropinocytosis is incompatible with chemotaxis.Semantic proximity Read ↗

Dictyostelium RasG is required for normal motility and cytokinesis, but not growth.Semantic proximity Read ↗

A<i>Dictyostelium</i>Homologue of WASP Is Required for Polarized F-Actin Assembly during ChemotaxisSemantic proximity Read ↗

Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles.Semantic proximity Read ↗

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.Semantic proximity Read ↗

Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC.Semantic proximity Read ↗

Dictyostelium stress-activated protein kinase alpha, a novel stress-activated mitogen-activated protein kinase kinase kinase-like kinase, is important for the proper regulation of the cytoskeleton.Semantic proximity Read ↗

Cellular distribution and functions of wild-type and constitutively activated Dictyostelium PakB.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.