Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation.

Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2002

Qin Mei, Kang Julia, Smith Carolyn Beebe

Abstract excerpt

In humans, failure to express the fragile X mental retardation protein (FMRP) gives rise to fragile X syndrome, the most common form of inherited mental retardation. A fragile X knockout (fmr1 KO) mouse has been described that has some of the characteristics of patients with fragile X syndrome, including immature dendritic spines and subtle behavioral deficits. In our behavioral studies, fmr1 KO mice exhibited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Avoidance Learning
Share to Brain Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dendrites

Share to Exploratory Behavior

Share to Fragile X Mental Retardation Protein

Share to Learning Disabilities

Share to Limbic System

Share to Parietal Lobe

Source

Open in PubMed Open full text

Identifiers

PMID: 12427968
DOI: 10.1073/pnas.242377399
PMCID: PMC137789

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation.PMID 12427968Read ↗

A null mutation for Fmr1 in female mice: effects on regional cerebral metabolic rate for glucose and relationship to behavior.Semantic proximity Read ↗

A mouse model of the fragile X premutation: effects on behavior, dendrite morphology, and regional rates of cerebral protein synthesis.Semantic proximity Read ↗

Reduced activity-dependent protein levels in a mouse model of the fragile X premutation.Semantic proximity Read ↗

Increased body weight in mice with fragile X messenger ribonucleoprotein 1 (Fmr1) gene mutation is associated with hypothalamic dysfunction.Semantic proximity Read ↗

Abnormal dendrite and spine morphology in primary visual cortex in the CGG knock-in mouse model of the fragile X premutation.Semantic proximity Read ↗

Decreased home cage movement and oromotor impairments in adult Fmr1-KO mice.Semantic proximity Read ↗

Cerebral protein synthesis in a knockin mouse model of the fragile X premutation.Semantic proximity Read ↗

Dendritic spine abnormalities in the occipital cortex of C57BL/6 Fmr1 knockout mice.Semantic proximity Read ↗

Anatomical phenotyping in a mouse model of fragile X syndrome with magnetic resonance imaging.Semantic proximity Read ↗

Behavioral Phenotype of Fmr1 Knock-Out Mice during Active Phase in an Altered Light/Dark Cycle.Semantic proximity Read ↗

Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8.Semantic proximity Read ↗

Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.