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Article

Cerebral protein synthesis in a knockin mouse model of the fragile X premutation.

ASN neuro - 1 Jan 2014

Qin Mei, Huang Tianjian, Liu Zhonghua, Kader Michael, Burlin Thomas, Xia Zengyan, Zeidler Zachary, Hukema Renate K, Smith Carolyn B

Abstract excerpt

The (CGG)n-repeat in the 5'-untranslated region of the fragile X mental retardation gene (FMR1) gene is polymorphic and may become unstable on transmission to the next generation. In fragile X syndrome, CGG repeat lengths exceed 200, resulting in silencing of FMR1 and absence of its protein product, fragile X mental retardation protein (FMRP). CGG repeat lengths between 55 and 200 occur in fragile X premutation...

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Source

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Identifiers

PMID: 25290064
DOI: 10.1177/1759091414551957
PMCID: PMC4187003

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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