Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abnormal dendrite and spine morphology in primary visual cortex in the CGG knock-in mouse model of the fragile X premutation.

Epilepsia - 1 Jun 2012

Berman Robert F, Murray Karl D, Arque Gloria, Hunsaker Michael R, Wenzel H Jürgen

Abstract excerpt

The fragile X mental retardation 1 gene (Fmr1) is polymorphic for CGG trinucleotide repeat number in the 5'-untranslated region, with repeat lengths <45 associated with typical development and repeat lengths >200 resulting in hypermethylation and transcriptional silencing of the gene and mental retardation in the fragile X Syndrome (FXS). Individuals with CGG repeat expansions between 55 and 200 are carriers of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia
Share to Dendrites
Share to Dendritic Spines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fragile X Mental Retardation Protein

Share to Fragile X Syndrome

Share to Pyramidal Cells

Share to Trinucleotide Repeats

Share to Visual Cortex

Source

Open in PubMed Open full text

Identifiers

PMID: 22612820
DOI: 10.1111/j.1528-1167.2012.03486.x
PMCID: PMC4316681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormal dendrite and spine morphology in primary visual cortex in the CGG knock-in mouse model of the fragile X premutation.PMID 22612820Read ↗

Dendritic spine abnormalities in the occipital cortex of C57BL/6 Fmr1 knockout mice.Semantic proximity Read ↗

A mouse model of the fragile X premutation: effects on behavior, dendrite morphology, and regional rates of cerebral protein synthesis.Semantic proximity Read ↗

Fragile X premutation rCGG repeats impair synaptic growth and synaptic transmission at Drosophila larval neuromuscular junction.Semantic proximity Read ↗

Fragile X mental retardation protein regulates new neuron differentiation in the adult olfactory bulb.Semantic proximity Read ↗

Sequence of abnormal dendritic spine development in primary somatosensory cortex of a mouse model of the fragile X mental retardation syndrome.Semantic proximity Read ↗

Pathogenic KIF5C mutation disrupts dendritic spine maturation and mitochondrial trafficking in neurodevelopmental disorders.Semantic proximity Read ↗

Analysis of FMR1 deletion in a subpopulation of post-mitotic neurons in mouse cortex and hippocampus.Semantic proximity Read ↗

Environmental enrichment reveals effects of genotype on hippocampal spine morphologies in the mouse model of Fragile X Syndrome.Semantic proximity Read ↗

Dendritic pathology in mental retardation: from molecular genetics to neurobiology.Semantic proximity Read ↗

Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice.Semantic proximity Read ↗

Intracisternal Gtf2i Gene Therapy Ameliorates Deficits in Cognition and Synaptic Plasticity of a Mouse Model of Williams-Beuren Syndrome.Semantic proximity Read ↗

Neuronal morphology in MeCP2 mouse models is intrinsically variable and depends on age, cell type, and Mecp2 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.