Article
A mouse model of the fragile X premutation: effects on behavior, dendrite morphology, and regional rates of cerebral protein synthesis.
Neurobiology of disease - 1 Apr 2011
Qin Mei, Entezam Ali, Usdin Karen, Huang Tianjian, Liu Zhong-Hua, Hoffman Gloria E, Smith Carolyn B
Abstract excerpt
Carriers of FMR1 premutation alleles have 55-200 CGG repeats in the 5' untranslated region of the gene. These individuals are at risk for fragile X associated primary ovarian insufficiency (females) and, in late life, fragile X associated tremor and ataxia syndrome (males, and to a lesser extent, females). Premutation carrier status can also be associated with autism spectrum disorder, attention deficit...
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