Article
Dendritic spine abnormalities in the occipital cortex of C57BL/6 Fmr1 knockout mice.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2005
McKinney Brandon C, Grossman Aaron W, Elisseou Nicholas M, Greenough William T
Abstract excerpt
Fragile X syndrome (FXS) is the most common form of inherited mental retardation. Observed neuropathologies associated with FXS include abnormal length, morphology, and density of dendritic spines, reported in individuals with FXS and in Fmr1 knockout (KO) mice, an animal model of FXS. To date, however, these neuropathologies have been studied in Fmr1 KO mice bred in a FVB background (a strain with genetic...
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