Article
Reduced activity-dependent protein levels in a mouse model of the fragile X premutation.
Neurobiology of learning and memory - 1 Mar 2014
von Leden Ramona E, Curley Lindsey C, Greenberg Gian D, Hunsaker Michael R, Willemsen Rob, Berman Robert F
Abstract excerpt
Environmental enrichment results in increased levels of Fmrp in brain and increased dendritic complexity. The present experiment evaluated activity-dependent increases in Fmrp levels in the motor cortex in response to training on a skilled forelimb reaching task in the CGG KI mouse model of the fragile X premutation. Fmrp, Arc, and c-Fos protein levels were quantified by Western blot in the contralateral motor...
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