Article
Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments.
Genes, brain, and behavior - 1 Aug 2010
Baker K B, Wray S P, Ritter R, Mason S, Lanthorn T H, Savelieva K V
Abstract excerpt
Impaired spatial learning is a prominent deficit in fragile X syndrome (FXS). Previous studies using the Fmr1 knockout (KO) mouse model of FXS have not consistently reported a deficit in spatial learning. Fmr1 KO mice bred onto an albino C57BL/6J-Tyr(c-Brd) background showed significant deficits in several primary measures of performance during place navigation and probe trials in the Morris water maze. Fmr1 KO...
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