Article
Structural diversity of the classical H-2 genes: K, D, and L.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1992
Pullen J K, Horton R M, Cai Z L, Pease L R
Abstract excerpt
Twenty-three class I DNA sequences, representing alleles of the H-2K, D, and L loci, were analyzed to assess patterns of nucleotide and amino acid diversity. Comparisons of the allelic and nonallelic sequences revealed locus specificity in regions encoding the leader peptides and the carboxyl-terminal segments of the Ag presenting molecules. Analyses focusing on the sequences that determine the Ag binding domains...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Genes, MHC Class I
- H-2 Antigens
- Mice
- Molecular Sequence Data
- Oligonucleotides
- Phylogeny
- Protein Conformation
- Sequence Alignment