Article
Competition within the virus-specific CD4 T-cell pool limits the T follicular helper response after influenza infection.
Immunology and cell biology - 1 Sept 2016
Olson Matthew R, Chua Brendon Y, Good-Jacobson Kim L, Doherty Peter C, Jackson David C, Turner Stephen J
Abstract excerpt
CD4 T follicular helper cells (TFH) are critical in the generation of potent and long-lived B-cell responses after viral infection. However, the factors that dictate the generation and maintenance of these cells are not fully understood. Here we use adoptive transfer of OTII T-cell receptor transgenic CD4 T cells, followed by infection with recombinant influenza A virus (IAV), as a means of identifying and...
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