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Article

¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models.

Journal of proteome research - 1 May 2015

Probert Fay, Rice Paul, Scudamore Cheryl L, Wells Sara, Williams Roger, Hough Tertius A, Cox I Jane

Abstract excerpt

The International Mouse Phenotyping Consortium program has been established to ascribe biological functions to systematically knocked-out (KO) genes by in vivo and ex vivo phenotyping. The plasma clinical chemistry screen includes an assessment of liver, kidney, and bone function and provides a basic lipid profile and histopathology reports on 32 tissues. We report on the inclusion of plasma analysis by proton...

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PMID: 25849460
DOI: 10.1021/pr501039k

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