Article
Enu mouse mutagenesis: generation of mouse mutants with aberrant plasma IgE levels.
International archives of allergy and immunology - 1 Jan 2000
Alessandrini F, Jakob T, Wolf A, Wolf E, Balling R, Hrabé de Angelis M, Ring J, Behrendt H
Abstract excerpt
BACKGROUND: The ENU Mouse Mutagenesis Project aims at a large-scale, systematic production of mouse mutants using the alkylating agent ethyl-nitrosourea (ENU). Offspring of mutagenized mice are subjected to a multiparameter screen to detect alterations in various phenotypes with the ultimate goal of identifying novel genes relevant for the expression of the phenotype. Using this approach, we have analyzed plasma...
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