Article
Influence of the apoA-II gene locus on HDL levels and fatty streak development in mice.
Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Jan 1993
Mehrabian M, Qiao J H, Hyman R, Ruddle D, Laughton C, Lusis A J
Abstract excerpt
Previous studies have shown that distal mouse chromosome 1 contains the apolipoprotein AII (apoAII) gene, encoding the second most abundant apolipoprotein in high density lipoproteins (HDLs), as well as a gene termed Ath-1 that controls aortic fatty streak development and HDL cholesterol levels in response to a high-fat, high-cholesterol diet. We report genetic studies confirming that the genes are distinct....
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