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Article

Mismatch repair genes in Lynch syndrome: a review

1 Jan 2009

Abstract excerpt

Lynch syndrome represents 1-7% of all cases of colorectal cancer and is an autosomal-dominant inherited cancer predisposition syndrome caused by germline mutations in deoxyribonucleic acid (DNA) mismatch repair genes. Since the discovery of the major human genes with DNA mismatch repair function, mutations in five of them have been correlated with susceptibility to Lynch syndrome: mutS homolog 2 (MSH2); mutL...

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Identifiers

PMID: 19466295
DOI: 10.1590/s1516-31802009000100010

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