Article
Mutations predisposing to hereditary nonpolyposis colorectal cancer.
Advances in cancer research - 1 Jan 1997
Peltomäki P, de la Chapelle A
Abstract excerpt
Since 1993 four genes have been identified that, when mutated, confer predisposition to a form of hereditary colon cancer (hereditary nonpolyposis colorectal cancer [HNPCC]). These genes belong to the Mut-related family of DNA mismatch repair genes whose protein products are responsible for the r...
Topics
- Adaptor Proteins, Signal Transducing
- Adenoma
- Adenosine Triphosphatases
- Carrier Proteins
- Chromosomes, Human, Pair 2
- Colonic Neoplasms
- Colorectal Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Repair
- DNA Repair Enzymes
- DNA-Binding Proteins
- Fungal Proteins
- Humans
- Microsatellite Repeats
- Mismatch Repair Endonuclease PMS2
- MutL Protein Homolog 1
- MutL Proteins
- MutS Homolog 2 Protein