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Article

[Microdissection and PCR-SSCP detected mutation and expression of p53 and K-ras gene in carcinogenesis and development of induced rat lung carcinoma].

Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 Aug 2002

Li Honggang, Liu Mingqiu, Diao Luming, Yu Lunyin, Chen Honglei, Chen Fuchun, Liu Xuan

Abstract excerpt

OBJECTIVE: To investigate the roles of p53 and K-ras gene in carcinogenesis and development of the lung carcinoma induced by 3-methylcholanthrene (MCA) and diethylinitrosamine (DEN) in Wistar rats, and to elucidate the relationships between the protein expression and gene mutation of p53 and K-ras. METHODS: Microdissection was used to obtain pure cell populations of each phase in the carcinogenesis and...

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PMID: 12417091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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