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Detection of K-ras and p53 mutations in sputum samples of lung cancer patients using laser capture microdissection microscope and mutation analysis.

Analytical biochemistry - 1 Jan 2004

Keohavong Phouthone, Gao Wei-Min, Zheng Kui-Cheng, Mady Hussam, Lan Qing, Melhem Mona, Mumford Judy

Abstract excerpt

Mutations in the p53 tumor suppressor gene and the K-ras oncogene have been frequently found in sputum and bronchoalveolar lavage (BAL) samples of lung cancer patients and other patients prior to presenting clinical symptoms of lung cancer, suggesting that they may provide useful biomarkers for early lung cancer diagnosis. However, the detection of these gene mutations in sputum and BAL samples has been...

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Identifiers

PMID: 14654050
DOI: 10.1016/j.ab.2003.09.030

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