Article
[Molecular mechanisms of lung cancer development at its different stages in nuclear industry workers].
Arkhiv patologii - 1 Jan 2000
Rusinova G G, Vyazovskaya N S, Azizova T V, Revina V S, Glazkova I V, Generozov E V, Zakharzhevskaya N B, Guryanov M Yu, Belosokhov M V, Osovets S V
Abstract excerpt
OBJECTIVE: to assess mutational events in exons 5, 7, and 8 of the p53 gene and to reveal mutant p53 protein in verified cases of morphologically altered (proliferative and precancerous changes, lung cancer) and histologically unaltered, lung tissues in workers exposed to occupational radiation. MATERIAL AND METHODS: The investigation used formalin-fixed paraffin-embedded unaltered and altered lung tissue blocks...
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