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Article

Wnt breakers in colon cancer.

Cancer cell - 1 Jan 2004

Clevers Hans

Abstract excerpt

Beta-catenin and Tcf4 are the downstream effectors of the Wnt signaling cascade. In colorectal cancer, mutations in Wnt cascade genes such as APC lead to the inappropriate formation of beta-catenin/Tcf4 complexes. Earlier work has predicted that disruption of the beta-catenin/Tcf4 protein-protein interaction could revert the proliferative phenotype of colorectal cancer cells. In this issue of Cancer Cell,...

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Topics

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Share to Adenomatous Polyposis Coli Protein
Share to beta Catenin
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Combinatorial Chemistry Techniques

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Share to Transcription Factor 7-Like 2 Protein

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Source

Identifiers

PMID: 14749120
DOI: 10.1016/s1535-6108(03)00339-8

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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